Jeffrey W. Peng

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Biography

B.S. Cornell University

Ph.D. Univ of Michigan, Biophysics

Postdoctoral Fellow: ETH-Zuerich Physical Chemistry

Senior Staff Investigator: Vertex Pharmaceuticals, Inc. (1994-2003) Cambridge MA, Structural Biology

Asst Prof. Univ of Notre Dame 2003- present

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Research Interests

Biophysics, NMR Spectroscopy, Molecular Flexibility and Dynamics

The Peng Lab works at the interface of physical and biological sciences to illuminate the role of atomic motion and conformational dynamics in biological function. Our main experimental approach is multi-dimensional NMR. We focus on the development and application of NMR methods to better understand the role of molecular dynamics in protein-ligand interactions, ligand transport, and drug design. We complement our NMR studies with molecular dynamics calculations, protein biochemistry, and collaborations with groups focused on theory and medicinal chemistry.

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Recent Papers

Peng T., Zintsmaster JS, Namanja AT, Peng JW (2007). Sequence-specific dynamics modulate recognition specificity in WW domains. Nat Struct Mol Biol Apr; 14(4):325-31. Epub 2007 Mar 4 Link

Namanja AT, Peng T, Zintsmaster JS, Elson AC, Shakour MG, Peng JW (2007). Substrate recognition reduces side-chain flexibility for conserved hydrophobic residues in human Pin1. Structure 15(3): 313-27.

Link
Peng, JW (2003). New probes of ligand flexibility in drug design: Transferred cross-correlated 13C CSA-dipolar relaxation at natural abundance. J. Am. Chem. Soc. 125: 11116-11130. Link
Peng JW (2001). Cross-correlated 19F relaxation measurements for the study of fluorinated ligand-receptor interactions. J. Magn. Reson. 153:32-47. Link
Peng JW, Schiffer CA, Xu P, van Gunsteren WF, Ernst RR (1996). Investigations of peptide hydration using NMR and molecular dynamics simulations: A study of the effects of water on the conformation and dynamics of Antamanide. J. Biomol. NMR 8:453-476.
Peng JW, Wagner G (1992). Mapping of spectral densities of NH bond motions in eglin c using heteronuclear relaxation experiments. Biochemistry 31:8571-8586. Link

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