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Lipid Binding C1 and C2 Domains

Left Panel Displays the C1 domain, a membrane penetrating module that interacts with diacylglycerol

Right panel displays the C2 domain of cytosolic phospholipase A2 alpha. A calcium (yellow), lipid and ceramide-1-phosphate (red) binding module.

 Lipid binding sites are a 'hot spot' for novel therapeutics against cancer, arthritis, and heart disease.  See Current Drug Targets article in 2008.
 

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